Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells. FoodChem Toxicol. 2009 Jul;47(7):1430-6.Epub 2009 Mar 27. Melchini A, Costa C, Traka M, Miceli N, Mithen R, De Pasquale R, Trovato A. Dip.Farmaco-Biologico,Facoltà di Farmacia, Università di Messina, VillaggioAnnunziata, 98168 Messina,Italy. Erucin (ER) is a dietaryisothiocyanate present in cruciferous vegetables, such as rocket salads (Erucasativa Mill.,Diplotaxis sp.), that has been recently considered a promising cancer chemopreventivephytochemical. Biological activity of ER was investigated on human lung adenocarcinoma A549 cells, analyzing its effects on molecular pathways involved in apoptosis and cell cycle arrest, such as PARP-1 cleavage, p53 and p21 protein expression. Our results show that ER affects the A549 cell proliferation, enhancing significantly p53 and p21 protein expression in a dose-dependent manner (p<0.001). PARP-1 cleavage occurs only after exposure to high concentrations of ER (50 microM), in accordance to previous studies showing similar bioactivity of other isothiocyanates (ITCs). Our study reports for the first time that the induction of p53, p21 and PARP-1


Food Sources of Phyto-Oestrogens

Food sources of phyto-oestrogens and their precursors in Europe. Br J Nutr. 2003 Jun;89 Suppl 1:S39-43. Fletcher RJ. Kellogg Company, Manchester, UK. Phyto-oestrogens are dietary components found in some plants, which act in vivo like weak oestrogens. They may reduce the risk of some degenerative diseases moderated by oestrogen, including breast cancer and osteoporosis. The most widely studied are the isoflavones genistein and daidzein from soyabeans, but lignans may be more prevalent in the European diet. Soya foods have traditionally been consumed in the Orient for millennia, and are now widely available to European consumers. Levels of isoflavone in soyabeans from published literature vary between 560 and 3810 mg/kg, depending on variety and growing conditions. Soya protein concentrates and isolates derived from soyabeans contain 466-615 mg isoflavones/kg. Traditional soya milk, bean curds, bean sprouts, etc. contain 13 to 2030 mg isoflavone/kg, depending on the starting raw material and final water content. Fermented foods have a different isoflavone conjugate profile, which may be important in absorption and metabolism. Soya analogues of European

Food Sources of Phyto-Oestrogens2018-10-04T15:02:58+00:00

Germinated Barley Foodstuff

Germinated Barley Foodstuff Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment. J Gastroenterol. 2003;38(2):134-41. Kanauchi O, Serizawa I, Araki Y, Suzuki A, Andoh A, Fujiyama Y, Mitsuyama K, Takaki K, Toyonaga A, Sata M, Bamba T. Nutrient Food and Feed Division, Kirin Brewery Co Ltd, 2-10-1 Shinkawa, Chuo-ku, Tokyo 104-8288, Japan. BACKGROUND: Germinated barley foodstuff (GBF), which contains glutamine-rich protein and hemicellulose-rich fiber, exhibits therapeutic effects in ulcerative colitis; however, its mechanism is still under investigation. The aim of this study was to evaluate the anti-inflammatory effects of GBF on colitis in terms of the epithelial inflammatory response. METHODS: Mice with dextran sulfate sodium-induced colitis were used. The effects of GBF on the colitis were evaluated by measuring the body weight; disease activity; mucosal damage (histology, mucosal inflammatory parameters, nuclear factor kappa B [NFkB] activation, and signal transducer and activator of transcription 3 [STAT3]); serum interleukin 6 (IL-6) level; cecal short-chain fatty acids (SCFAs); and bile acid contents. RESULTS:GBF significantly prevented disease activity

Germinated Barley Foodstuff2018-10-04T15:03:37+00:00

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