Sulforaphane Induces Cell

Sulforaphane Induces Cell-Cycle Arrest and Apoptosis in Cultured Human Lung Adenocarcinoma LTEP-A2 Cells and Retards Growth of LTEP-A2 Xenografts in Vivo.

J Nat Prod. 2008 Oct 15.

Liang H, Lai B, Yuan Q.

Sulforaphane, a glucosinolate-derived isothiocyanate found in the cruciferous vegetable broccoli, is considered an anticarcinogenic component. In the present study, the proliferation and apoptosis induction in human lung adenocarcinoma LTEP-A2 cells by sulforaphane was investigated. Sulforaphane caused G 2/M-phase arrest ( p < 0.05) and increase of apoptotic cell fraction ( p < 0.05) in a time- and dose-dependent manner. Intraperitoneal injection of sulforaphane significantly inhibited growth of LTEP-A2 xenografts in nude mice, and 9 days after tumor cell implantation with 100 mg/kg intraperitonealinjection of sulforaphane, the average tumor weights in sulforaphane treated mice was >70% lower than that of the control mice.



Note from ISS:  Several crucifer sprouts including broccoli sprouts are currently the most potent natural source of sulforaphane known.  They often produce 10 to 100 times the amount of sulforaphane as their corresponding mature vegetables. (“Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.”, Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10367-72.)